The three best characterized Wnt signaling pathways are the canonical Wnt pathway, the noncanonical planar cell polarity pathway, and the noncanonical Wnt/calcium pathway.

This review explores the molecular mechanisms underlying Wnt pathway activation, highlighting its critical components and examining upstream factors that may influence its function. Additionally, the …

Jan 3, 2022 · In this article, we comprehensively review the Wnt/β-catenin pathway from the above five aspects in combination with the latest research.

Jun 16, 2025 · Wnt refers to a family of secreted proteins that facilitate communication between cells in virtually all animal species. The name “Wnt” combines “Wingless,” a gene from the fruit fly …

Aug 29, 2025 · Wnt signaling is one of the cell’s most complex and important signal transduction pathways. This pathway, which is divided into additional sub-pathways, regulates cell growth, …

Jun 18, 2025 · Explore the Wnt/β-catenin signaling pathway, understand its components, regulation, and therapeutic potential in disease.

Explore Wnt signal transduction pathway mechanisms. Learn how Wnt signaling pathways influence development, stem cell behavior & adult tissue homeostasis.

4 days ago · β-catenin is a critical effector of the Wnt pathway and a key component of the cadherin complex. Whether Wnt-regulated cytoplasmic β-catenin interacts with the cadherin-associated pool …

In this Review, we provide an update of the core Wnt/β-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the …

5 days ago · Tegavivint Is the First Wnt/β-Catenin Inhibitor to Demonstrate Tolerability and Monotherapy Clinical Activity in Complex Solid Tumors Osteosarcoma Program Builds on Clinical Benefit observed …